Research at UCLA AIR-B

UCLA AIR-B investigators Kasari, McCracken, Frankel, and Sabb are engaged in a variety of research which relate to the AIR-B mission. These include the four Projects (see Protocols 1, 2, 3) supported by the AIR-B and one ARRA Supplement grant (Protocol 4; Orlich, PI, Univ. of Washington).

Other research in the Kasari Lab includes proof of concept interventions for infants at risk for ASD; piloting the development of interventions targeting language acquisition and communication skills for non-verbal children with ASD, and examining the effects of targeted joint attention and play skill training as augmentations of intensive applied behavioral analysis (ABA) intervention.

McCracken and colleagues are investigating the efficacy and brain mechanisms of risperidone as a treatment for impairing repetitive behavior in ASD; the behavioral and cognitive effects of guanfacine as a treatment for disruptive behaviors in children and adolescents with ASD; and examination of the moderating effects of gene variants on medication response in clinical trials of ASD.

Frankel is continuing studies of social skill training approaches for a range of populations including children with ASD.

Sabb is testing the utility of web-based phenotyping of cognitive control profiles, and will be piloting the use of cognitive training approaches using web-based methods for children with ADHD and related disorders.